EmbryoPhenomics research team
Part of the Ecophysiology and Development Research Group
See some of the fascinating organisms and stages of life that the team works with.
Biology is complex, and early biological development is the most dynamic period of life. A time when animals must put themselves together while maintaining a functional phenotype with incredible temporal, spatial and functional change.
Measuring this period of life has always challenged biologists, but has also never been so important to address challenges ranging from protecting biodiversity, ensuring food security and sensing biological impacts of environmental degradation.
is a research team, led by
Dr Oliver Tills , that is pushing the boundaries of measuring the process of embryonic development and other complex, . The team applies bioimaging-based sensing approaches to measuring the development of form and function in developing animals ÂÌñ»»ÆÞ“ both in the laboratory and out in the environment.
They have a heavy reliance on innovation, supported by a rapid manufacture R&D workshop at ÂÌñ»»ÆÞ Science Park, integrating 3D printing, artificial intelligence and embedded electronics to measure biology in new ways.
The team use the concept of phenomics in their research ÂÌñ»»ÆÞ“ high-dimensional organismal phenotyping, an approach spearheaded in medicine and crop science, but which has remained largely inaccessible in biology more broadly. Phenomics is highlighted as being key for advancing biology in the 21st century. EmbryoPhenomics is a strong proponent for biological development as a model for phenomics ÂÌñ»»ÆÞ“ due to the high level of spatial and functional change occurring at timescales ranging from seconds to days, in small stages of life that can have extremely high sensitivity to the environment1,2.
Instrumentation
EmbryoPhenomics is applying opensource approaches to research ÂÌñ»»ÆÞ“ releasing 3, 4 and as opensource. The team's rationale is clear ÂÌñ»»ÆÞ“ to maximise the impact of its research by making it as broadly accessible as possible. The benefits of opensource are well established, ranging from meeting global challenges, democratising science, through to improved return on investment to funders.
Despite being an opensource lab, the teamÂÌñ»»ÆÞ™s innovations are available for sale through ÂÌñ»»ÆÞ“ a not-for-profit Community Interest Company established by the team to support researchers. Many people lack the time, facilities or inclination to build their own hardware ÂÌñ»»ÆÞ“ Phenomyx prevents this from being a barrier via the sale and support of technologies.
EmbryoPhenomics technologies have broad relevance to research, education and industry ÂÌñ»»ÆÞ“ consequently, the team takes every effort to make its innovations and accompanying research versatile, user-friendly and reproducible.
Video is a central enabler of the EmbryoPhenomics team's research and provides a unique window onto the dynamic ÂÌñ»»ÆÞ“ and otherwise hidden ÂÌñ»»ÆÞ“ world of early development. The team uses these approaches for both teaching and research, including in schools; is a tool for aiding in the learning of osmosis at KS3 and higher.
Contact oliver.tills@plymouth.ac.uk for further information about the EmbryoPhenomics research team and Phenomyx CIC. Visit the for additional information about the team.
Key publications
- Ibbini, Z., Bruning, M., Allili, S., Holmes, L.A., Tully, E., McCoy, J., Larsen, B., Wilson, T., Ludford, G., Barrett-Kelly, J., Spicer, J.I., Tills, O., 2024. LabEmbryoCam: An opensource phenotyping system for developing aquatic animals. HardwareX 20, e00602.
- Tills, O., Ibbini, Z., Spicer., JI. 2024. Bioimaging and the future of whole-organismal developmental physiology. Comparative Biochemistry and Physiology, Part A, 111783.
- Tills, O, Spicer JI, Grimmer A, Marini S, Jie, VW. 2018 ÂÌñ»»ÆÞ˜A high-throughput and open-source platform for embryo phenomicsÂÌñ»»ÆÞ™. PLoS Biology 16, e3000074 (2018).
- Ibbini Z, Truebano M, Spicer JI, McCoy JCS, Tills O. 2024. Dev-ResNet: Automated developmental event detection using deep learning. J. Exp. Biol. 227, 247046.